What to Take When You Can’t Sleep

A good night’s sleep is crucial for overall health and well-being, yet many individuals find themselves struggling with sleeplessness, whether due to stress, lifestyle factors, or underlying health conditions. While sleep problems can sometimes be temporary, persistent insomnia can lead to significant physical and mental health issues. If you’re having trouble sleeping, you may wonder what you can take to help fall asleep and improve your sleep quality. The answer depends on the underlying cause of your insomnia, and the options range from over-the-counter supplements to prescription medications. Below, we explore various remedies that can help when you can't sleep, both natural and pharmaceutical, and how to determine what might be best for you.

1. Over-the-Counter Sleep Aids

For many individuals, over-the-counter (OTC) sleep aids are a go-to solution when they struggle with occasional sleeplessness. These medications are typically sold without a prescription and contain ingredients designed to promote drowsiness or relaxation.

Diphenhydramine or Doxylamine

One of the most common OTC sleep aids is diphenhydramine, an antihistamine commonly found in medications like Benadryl and “PM” medications. Doxylamine is found in Unisom. Diphenhydramine and doxylamine work by blocking histamine receptors in the brain, which reduces wakefulness and promotes sleepiness. While it can be effective for occasional use, it’s important to note that this drug can cause grogginess the next morning, and repeated use may lead to tolerance, meaning its effectiveness diminishes over time. There is concern that long-term use may contribute to dementia risk.

Melatonin

Melatonin is a hormone that your body naturally produces to regulate the sleep-wake cycle. Supplementing with melatonin is a popular remedy for people who have difficulty falling asleep, particularly for those with circadian rhythm disorders or those who are adjusting to new time zones (like in the case of jet lag). Melatonin supplements are available in various doses, and they are generally considered safe for short-term use. However, it’s best to consult a healthcare professional about the right dosage and timing, as too much melatonin can actually disrupt your sleep cycle.

Valerian Root

Valerian root is a herbal supplement often used to treat insomnia and anxiety. It has sedative properties and may help some individuals fall asleep more quickly. The exact way it works is not fully understood, but it is believed to increase the amount of gamma-aminobutyric acid (GABA) in the brain, which promotes relaxation and sleep. While valerian root is generally considered safe for short-term use, it can cause side effects such as headaches or dizziness in some individuals. It’s advisable to use it under the guidance of a healthcare provider.

2. Prescription Sleep Medications

If OTC options do not provide the relief you need, prescription medications might be an option. However, these medications are usually prescribed for individuals who have chronic insomnia or other sleep disorders. Prescription sleep aids should only be used under the supervision of a doctor because they may cause side effects, interactions with other medications, and potential dependency.

Benzodiazepines

Benzodiazepines, such as temazepam (Restoril), lorazepam (Ativan), and alprazolam (Xanax), are often prescribed for short-term insomnia. These medications work by enhancing the effects of GABA, a neurotransmitter that calms brain activity and induces sleep. While they are effective, they are typically not recommended for long-term use due to their potential for dependence and withdrawal symptoms. Benzodiazepines can also cause side effects like dizziness, memory issues and dementia, and daytime drowsiness.

Non-Benzodiazepine Sedatives

Non-benzodiazepine sleep aids, such as zolpidem (Ambien) and eszopiclone (Lunesta), are commonly prescribed to treat insomnia. These medications have a similar effect to benzodiazepines but are often considered to be less habit-forming. Non-benzodiazepines work by targeting the brain’s receptors responsible for sleep and can help people fall asleep more quickly and stay asleep throughout the night. However, like benzodiazepines, they can cause drowsiness the next day, memory impairment, sleep-related behaviors, and have the potential for misuse.

Antidepressants

Certain antidepressants, like trazodone (Desyrel) and amitriptyline (Elavil), are sometimes prescribed off-label to help with sleep. These medications have sedative effects and are often used for individuals who experience insomnia due to anxiety or depression. They are generally considered safe for long-term use, but side effects can include daytime grogginess, dizziness, and weight gain. Additionally, these medications can interact with other antidepressants and should only be used under a doctor’s supervision.

3. Natural and Herbal Remedies

For those who prefer natural approaches, there are several herbal remedies and lifestyle changes that may help promote relaxation and improve sleep. While the evidence for these remedies varies, many people find them helpful for reducing stress and encouraging restful sleep.

Lavender

Lavender is a widely used herb known for its calming and relaxing properties. Studies have shown that lavender can help reduce anxiety, stress, and insomnia. You can use lavender in various forms, such as essential oils, teas, or supplements. Diffusing lavender oil in your bedroom before bed or adding a few drops to your pillow can create a soothing environment that promotes better sleep.

Chamomile

Chamomile is another herb commonly used to improve sleep quality. It has mild sedative effects and is often consumed as a tea before bed. Chamomile has been used for centuries to treat anxiety and insomnia, and it may help calm the nervous system, making it easier to relax and fall asleep. While it is generally considered safe, some people may experience allergic reactions, particularly those who are allergic to ragweed or daisies.

Magnesium

Magnesium is a mineral that plays a vital role in many bodily functions, including muscle relaxation and sleep regulation. Studies have shown that magnesium supplementation may help improve sleep quality, especially for those with low magnesium levels. Magnesium can be found in foods like leafy greens, nuts, and seeds, or it can be taken as a supplement. Some people prefer magnesium supplements or magnesium oil for topical use to promote relaxation before bedtime.

4. Lifestyle and Behavioral Changes

Sometimes, sleep difficulties are not solely resolved by taking medication or supplements. Lifestyle changes and good sleep hygiene can have a significant impact on improving your sleep quality in the long term. A few strategies to consider include:

• Establishing a consistent bedtime routine: Going to bed and waking up at the same time every day helps regulate your body’s internal clock.

• Creating a calming environment: Keeping your bedroom cool, dark, and quiet can help signal to your body that it’s time to sleep.

• Limiting caffeine and alcohol: Both caffeine and alcohol can disrupt your sleep patterns, so try to avoid consuming them several hours before bed.

• Managing stress: Practicing relaxation techniques such as meditation, deep breathing, or gentle stretching before bed can help reduce stress and anxiety, making it easier to fall asleep.

5. When to See a Doctor

If you’ve tried over-the-counter remedies, herbal supplements, and lifestyle changes without success, it may be time to consult a doctor. Persistent sleep problems could be indicative of an underlying condition, such as sleep apnea, restless leg syndrome, anxiety, or depression. A healthcare provider can help determine the root cause of your sleep difficulties and provide more targeted treatment options. Cognitive behavioral therapy for insomnia (CBTI) is the preferred treatment for insomnia that persists beyond 3 months.

Conclusion

There are a variety of options to consider when you can’t sleep, ranging from over-the-counter supplements to prescription medications and natural remedies. What you choose to take depends on your individual circumstances, including the underlying cause of your sleep issues. While medications can provide short-term relief, incorporating lifestyle changes and improving sleep hygiene may offer long-lasting benefits for your sleep quality. Ultimately, if sleeplessness persists, it’s important to seek professional advice to address any potential underlying health concerns.

This article was created using OpenAI’s ChatGPT on February 21, 2025 and it was personally reviewed and edited by Brandon Peters, M.D. to ensure its accuracy. This use of augmented intelligence in this way allows the creation of health information that can be trusted.

What Substances Can Be Causes of Nightmares?

Nightmares are vivid and often distressing dreams that can lead to feelings of fear, anxiety, and confusion upon waking. While various psychological factors contribute to nightmares, certain substances can also play a significant role in triggering these unsettling experiences. Understanding how these substances influence sleep can help individuals make informed choices about their consumption and potentially mitigate the occurrence of nightmares.

1. Alcohol

Alcohol is one of the most commonly consumed substances that can disrupt sleep patterns and contribute to nightmares. Initially, alcohol may induce feelings of relaxation and drowsiness, making it easier to fall asleep. However, as the body metabolizes alcohol, its effects can lead to fragmented sleep.

Research shows that alcohol can suppress rapid eye movement (REM) sleep, the stage of sleep most closely associated with dreaming. As the body processes alcohol, REM sleep can rebound, often leading to increased intensity and frequency of dreams. When individuals wake from these heightened REM episodes, they may recall vivid nightmares that are often emotionally charged. Furthermore, alcohol can exacerbate sleep disorders like sleep apnea, further contributing to poor sleep quality and nightmare occurrences.

2. Caffeine

Caffeine, a widely consumed stimulant found in coffee, tea, energy drinks, and certain medications, is known for its ability to enhance alertness and reduce fatigue. However, its effects on sleep can be detrimental. Caffeine can interfere with the ability to fall asleep and reduce overall sleep quality. When consumed later in the day, it can lead to insomnia, which is closely linked to increased anxiety and nightmares.

Research has shown that individuals who consume caffeine, particularly in high doses, may experience more vivid dreams and nightmares. This could be due to caffeine's stimulatory effects on the brain, which may increase brain activity during sleep. Additionally, caffeine can lead to restlessness and a fragmented sleep cycle, both of which are associated with a higher likelihood of experiencing nightmares.

3. Nicotine

Nicotine, a primary component of tobacco, is another substance linked to sleep disturbances and nightmares. As a stimulant, nicotine can lead to increased heart rate and blood pressure, making it harder to relax and fall asleep. Smokers often report difficulty sleeping, leading to reduced sleep duration and quality.

Nicotine withdrawal during the night can also lead to disrupted sleep patterns. When individuals try to quit smoking, the withdrawal symptoms can manifest during sleep, resulting in increased anxiety and nightmares. Research indicates that smokers experience more nightmares compared to non-smokers, particularly when they have reduced or stopped nicotine consumption.

4. Medications

Certain medications can contribute to the onset of nightmares, either as a direct side effect or due to their impact on sleep architecture. Some of the common categories of medications associated with nightmares include:

• Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants can affect sleep patterns and have been linked to increased vivid dreams and nightmares. While they can help alleviate symptoms of depression and anxiety, some individuals may experience heightened dream activity, leading to distressing dreams.

• Beta Blockers: These medications, often prescribed for hypertension and anxiety, can affect the REM sleep cycle and have been associated with an increase in nightmares. They can also affect the normal production and release of melatonin. Patients taking beta blockers have reported more frequent nightmares, particularly when starting or adjusting their dosage.

• Stimulants: Medications for attention-deficit hyperactivity disorder (ADHD), such as amphetamines, can impact sleep quality and lead to increased occurrences of nightmares. The stimulatory effects of these medications can interfere with the natural sleep cycle, contributing to vivid and unsettling dreams.

• Corticosteroids: These anti-inflammatory medications can lead to mood changes and sleep disturbances. Individuals taking corticosteroids have reported experiencing more vivid and distressing dreams, including nightmares.

5. Recreational Drugs

Various recreational drugs can also play a role in the development of nightmares. Substances such as marijuana, hallucinogens, and psychedelics can significantly alter sleep patterns and dream experiences.

• Marijuana: While some people use marijuana to help with sleep, it can have paradoxical effects on dream recall and intensity. Individuals who regularly use marijuana often report fewer dreams overall, but when they stop, they may experience a rebound effect, leading to an increase in vivid dreams and nightmares during withdrawal.

• Hallucinogens: Drugs like LSD and psilocybin can dramatically alter perception and consciousness. These substances can lead to intense and sometimes terrifying dream experiences, as they impact the brain's neurotransmitter systems associated with mood and perception.

• MDMA: Commonly known as ecstasy, MDMA can affect sleep quality and has been reported to cause vivid nightmares after its effects wear off. Users often experience emotional highs followed by lows, which can influence dream content and emotional tone.

6. Supplements

Some supplements may also influence sleep and dream quality. Melatonin may cause nightmares as a side effect. In addition, valerian root and kava are often used for their calming effects, but they may also have side effects. While they may promote relaxation, excessive use can lead to disrupted sleep patterns and, in some cases, nightmares.

Conversely, other herbs like St. John's Wort, commonly used for depression, can alter sleep architecture and contribute to the experience of vivid dreams and nightmares, particularly when taken in combination with other medications.

Conclusion

Understanding the substances that can trigger nightmares is crucial for anyone seeking to improve their sleep quality. Alcohol, caffeine, nicotine, certain medications, recreational drugs, and even some supplements can all contribute to the occurrence of nightmares. By identifying and moderating the use of these substances, individuals can potentially reduce the frequency and intensity of their nightmares, leading to a more restful night’s sleep.

If nightmares persist, it may be beneficial to consult a healthcare professional for guidance. They can help assess the situation, consider any underlying psychological or medical issues, and develop a tailored approach to improve sleep quality and overall well-being.

This article was created using OpenAI’s ChatGPT on October 3, 2024 and it was personally reviewed and edited by Brandon Peters, M.D. to ensure its accuracy. This use of augmented intelligence in this way allows the creation of health information that can be trusted.